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University of Iowa, The Roy J. Huntington disease HD is a devastating illness, although its autosomal dominant genetic transmission allows a unique opportunity to study apparently healthy individuals before manifest disease. Attempts to study early disease are not unique in neurology e. A NIH study in its ninth year PREDICT-HD has offered a glimpse into the transition from an apparently healthy state to an obviously diseased state, and can serve as a model for many other genetic diseases, both neurological and non-neurological. Publication of the human genome has accentuated the desired paradigm shift in medicine from treatment of disease following diagnosis to the prediction and prevention of disease in healthy persons. Huntington disease HD , an autosomal dominant progressive neurological disease with an identified gene mutation [ 1 ], has proven helpful to expedite preparations for preventive clinical trials in neurodegenerative diseases.
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